Tetrahedron

l-Proline-derived ligands to mimic the '2-His-1-carboxylate'triad of the non-haem iron oxidase active site

VJ Dungan, SM Wong, SM Barry, PJ Rutledge

Index: Dungan, Victoria J.; Wong, Shwo Mun; Barry, Sarah M.; Rutledge, Peter J. Tetrahedron, 2012 , vol. 68, # 15 p. 3231 - 3236

Full Text: HTML

Citation Number: 13

Abstract

Non-haem iron (II) oxidases (NHIOs) catalyse a variety of oxidative transformations in biology. The iron-binding environment of the NHIO active site typically incorporates a '2-His- 1-carboxylate'facial triad of amino acid side-chains, a motif that has emerged as a defining feature of the enzyme family. Towards the goal of biomimetic, iron-mediated C–H activation we have synthesized a series of peptidomimetic ligands from l-proline. By coupling l- ...