Synthesis and pharmacological studies of N-substituted 6-[(2-aminoethyl) amino]-1, 3-dimethyl-2, 4 (1H, 3H)-pyrimidinediones, novel class III antiarrhythmic agents

T Katakami, T Yokoyama, M Miyamoto…

Index: Katakami; Yokoyama; Miyamoto; Mori; Kawauchi; Nobori; San-nohe; Kaiho; Kamiya Journal of Medicinal Chemistry, 1992 , vol. 35, # 18 p. 3325 - 3330

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Citation Number: 13

Abstract

A series of 64 (2-aminoethyl) amino]-1, 3-dimethyl-2, 4 (~, 3H)-pyrim. idjnedione derivatives were synthesized and studied for their class I11 electrophysiological activity and class I1 (&blocking) effects in in vitro and in vivo models. Structure-activity relationships are discussed for a series of compounds. Several members of this series prolonged the action potential duration at 75% repolarization of isolated canine Purkinje fibers and were 10-30- ...

~82%

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