Affinity of 10-(4-methylpiperazino) dibenz [b, f] oxepins for clozapine and spiroperidol binding sites in rat brain

…, HE Smith, PL Mobley, DH Manier…

Index: Harris, Terry W.; Smith, Howard E.; Mobley, Philip L.; Manier, D. Hal; Sulser, Fridolin Journal of Medicinal Chemistry, 1982 , vol. 25, # 7 p. 855 - 858

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Citation Number: 28

Abstract

10-(4-Methylpiperazino) dibenz [b, floxepins were prepared and evaluated as potential antipsychotic agents using specific clozapine [8-chloro-ll-(4-methylpiperazino)-5H-dibenzo [b, e][1, 4] diazepine] binding sites in rat forebrain that are noncholinergic and nondopaminergic in nature and from which [3H] clozapine is displaced by known antipsychotic agents.[3H] Clozapine binding in the presence of atropine represents ...