Design, synthesis and in vivo anticonvulsant screening in mice of Novel phenylacetamides

AV Shindikar, F Khan, CL Viswanathan

Index: Shindikar; Khan; Viswanathan European Journal of Medicinal Chemistry, 2006 , vol. 41, # 6 p. 786 - 792

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Citation Number: 35

Abstract

A set of seven novel N-substituted 2-anilinophenylacetamides were designed by pharmacophore generation and using flexible alignment module of MOE software. The novel molecules were synthesized and screened for anticonvulsant activity in Swiss albino mice by MES and ScPTZ induced seizure tests. Test compounds were found to be potent in MES test. Compounds 12 and 14 were found to be more potent with ED50 values 24.0 ...