A new, versatile annulation route for the synthesis of substituted quinolines has been developed by using regioisomeric bifunctional pyridine derivatives with vicinal bromomethyl and (phenylsulfony1) methyl groups. The sequence consists of (a) alkylation of substituted diethyl malonates with these (bromomethy1) pyridines and (b) intramolecular acylation with concomitant decarboxylation and leads to quinoline derivatives variously substituted in ...
