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Synthesis of N-substituted-N-acylthioureas of 4-substituted piperazines endowed with local anaesthetic, antihyperlipidemic, antiproliferative activities and …

…, L Mosti, A Capuano, F Mazzeo, G Falcone, W Filippelli

Index: Ranise, Angelo; Spallarossa, Andrea; Bruno, Olga; Schenone, Silvia; Fossa, Paola; Menozzi, Giulia; Bondavalli, Francesco; Mosti, Luisa; Capuano, Annalisa; Mazzeo, Filomena; Falcone, Giuseppe; Filippelli, Walter Farmaco, 2003 , vol. 58, # 9 p. 765 - 780

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Citation Number: 35

Abstract

Three series of N-acyl and N-cyclohexyl-or N-methyl or N-phenyl-thioureas of 4-substituted (methyl, phenyl, 2-pyridyl) piperazines (4–12) were synthesised according to a highly convergent one-pot procedure and tested in vivo (local anaesthetic, anti- hyperlipoproteinemic, analgesic, anti-inflammatory, antiarrythmic activities) and in vitro (antiaggregating and, for some selected derivatives, antiproliferative activities) ...