Tetrahedron

A convenient one-pot synthesis of thiazol-2-imines: application in the construction of pifithrin analogues

S Murru, CB Singh, V Kavala, BK Patel

Index: Murru, Siva; Singh; Kavala, Veerababurao; Patel, Bhisma K. Tetrahedron, 2008 , vol. 64, # 8 p. 1931 - 1942

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Citation Number: 64

Abstract

For the first time a reaction intermediate has been isolated giving further insight into the mechanism of thiazol-2-imine formation. The first step of the reaction requires a basic medium, while the second step is an acid mediated E1 elimination reaction. An efficient one- pot synthesis of substituted thiazol-2-imines have been achieved by the condensation of carbonyl compounds with thioureas and 1, 3-disubstituted thioureas using 1, 1′-(ethane- ...