Conformational Studies on Peptides of α??Aminoxy Acids with Functionalized Side??Chains

D Yang, GJ Liu, Y Hao, W Li, ZM Dong…

Index: Yang, Dan; Liu, Guo-Jun; Hao, Yu; Li, Wei; Dong, Ze-Min; Zhang, Dan-Wei; Zhu, Nian-Yong Chemistry - An Asian Journal, 2010 , vol. 5, # 6 p. 1356 - 1363

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Citation Number: 8

Abstract

Abstract Peptides of homochiral α-aminoxy acids of nonpolar side chains can form a 1.8 8- helix. In this paper, we report the conformational studies of α-aminoxy peptides 1, 2, 3, which have functionalized side chains, in both nonpolar and polar solvents. 1 H NMR, XRD, and FTIR absorption studies confirm the presence of the eight-membered-ring intramolecular hydrogen bonds (the NO turns) in nonpolar solvents as well as in methanol. CD studies of ...