Structure–activity relationship in the antitumor activity of 6-, 8-or 6, 8-substituted 3-benzylamino-β-carboline derivatives

…, T Tsutsumi, S Tamura, N Sakai, T Konakahara

Index: Ikeda, Reiko; Kimura, Takanori; Tsutsumi, Tatsuya; Tamura, Syunsuke; Sakai, Norio; Konakahara, Takeo Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 10 p. 3506 - 3515

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Citation Number: 16

Abstract

We synthesized 47 kinds of 3-amino-or 3-benzylamino-β-carboline derivatives with a substituent on the 6-, 8-, or 6, 8-carbon atoms and evaluated their antitumor activities for Hela S-3 and Sarcoma 180 cell lines using a 3-(4, 5-dimethylthiazol-2-yl)-2, 5- diphenyltetrazolium bromide assay. Consequently, we succeeded to develop 3- benzylamino-8-methylamino-β-carboline (17a) and 8-methylamino-3-(3-phenoxybenzyl) ...