In Vitro Photodynamic Activity of 5, 15??bis (3??Hydroxyphenyl) porphyrin and Its Halogenated Derivatives Against Cancer Cells

…, AMA Rocha Gonsalves, M Abrantes…

Index: Serra, Armenio; Pineiro, Marta; Santos, Catarina Isabel; Rocha Gonsalves, Antonio Manuel D'A.; Abrantes, Margarida; Laranjo, Mafalda; Botelho, Maria Filomena Photochemistry and Photobiology, 2010 , vol. 86, # 1 p. 206 - 212

Full Text: HTML

Citation Number: 16

Abstract

Abstract 5, 15-Diarylporphyrins (1-5) with hydroxyl groups and halogens as substituents were prepared by condensation between unsubstituted dipyrromethane and halogenated m- hydroxybenzaldehydes. Photophysical properties show that the nonhalogenated porphyrin 1 has higher fluorescence yield but lower singlet oxygen formation quantum yield than the halogenated derivatives due to the heavy atom effect. The in vitro activity of these ...