Preparation of Aryloxetanes and Arylazetidines by Use of an Alkyl− Aryl Suzuki Coupling

…, C Kaub, DJR O'Mahony, RJ Johnson, M Cox…

Index: Duncton, Matthew A. J.; Estiarte, M. Angels; Tan, Darlene; Kaub, Carl; O'Mahony, Donogh J. R.; Johnson, Russell J.; Cox, Matthew; Edwards, William T.; Wan, Min; Kincaid, John; Kelly, Michael G. Organic Letters, 2008 , vol. 10, # 15 p. 3259 - 3262

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Citation Number: 50

Abstract

The introduction of privileged modules with low molecular weight and hydrophilic character into compounds with biological activity is an ongoing challenge within modern medicinal chemistry. The oxetan-3-yl substituent was recently disclosed as one such privileged motif, with demonstrated benefits for property-guided drug discovery and a remarkable ability to alter the pharmacological character of biologically active molecules.(1) For instance, oxetanes can ...