Tetrazoles: LIII. Microwave-activated acylation of 5-substituted tetrazoles

YA Efimova, TV Artamonova, GI Koldobskii

Index: Efimova; Artamonova; Koldobskii Russian Journal of Organic Chemistry, 2008 , vol. 44, # 9 p. 1345 - 1347

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Citation Number: 16

Abstract

Abstract The acylation of 5-aryl (hetaryl) tetrazoles with acetic and benzoic anhydrides under microwave irradiation gave the corresponding 2-substituted 5-methyl-and 5-phenyl-1, 3, 4- oxadiazoles in high yields. The use of microwave activation reduces the reaction temperature by 30–40° C and shortens the reaction time by a factor of 5 to 7.