Synthesis and biological properties of side-chain-modified bleomycins

WJ Vloon, C Kruk, UK Pandit, HP Hofs…

Index: Vloon; Kruk; Pandit; Hofs; McVie Journal of Medicinal Chemistry, 1987 , vol. 30, # 1 p. 20 - 24

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Citation Number: 32

Abstract

New side-chain-modified bleomycins (BLMs) 3a-k have been synthesized by the reaction of demethyl BLM A2 with a-bromoacetamides (2a-k). The structures of these BLM analogues have been established by comparison of their NMR spectra with the corresponding spectra of model thiazole derivatives. Mass spectra (FAB) of the modified BLMs are not informative, since the fragmentation patterns exhibit a loss of the modified chain moiety, presumably in ...