Anti-MRSA cephems. Part 3: additional C-7 acid derivatives

DM Springer, BY Luh, JT Goodrich…

Index: Springer, Dane M; Luh, Bing Yu; Goodrich, Jason T; Bronson, Joanne J Bioorganic and medicinal chemistry, 2003 , vol. 11, # 2 p. 281 - 291

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Citation Number: 7

Abstract

Twenty-seven novel cephalosporin derivatives with activity against methicillin-resistant Staphylococcus aureus (MRSA) are described. The compounds contain novel acid moieties at C-7 that were synthesized using nucleophilic aromatic substitution reactions and Stille couplings. The most interesting compound (6) displayed an MIC90 against MRSA of 3.7 μg/mL, and an average PD50 of 3.9 mg/kg.

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