Synthesis and reactivity of 2-formylindole and 5-formylpyrrole derivatives

…, VA Azimov, LM Alekseeva, VG Granik

Index: Ryabova, S. Yu.; Trofimkin, Yu. I.; Azimov, V. A.; Alekseeva, L. M.; Granik, V. G. Pharmaceutical Chemistry Journal, 1995 , vol. 29, # 2 p. 127 - 131 Khimiko-Farmatsevticheskii Zhurnal, 1995 , vol. 29, # 2 p. 46 - 50

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Abstract

Abstract The methylation of 2-formyl-3-hydroxyindole was studied, and the sequence of introduction the methyl groups was traced by 1 H NMR spectroscopy. The O-methyl, N- methyl, and N, O-methyl derivatives of 2-formylindole, and also the O-methyl and N-methyl derivatives of 2-methyl-3-ethoxycarbonyl-4-hydroxypyrrole were synthesized. Novel derivatives of indolyl-and pyrrolylacrylic acids were obtained on the basis of some O-and ...