2, 4-Dihydroxyacetophenone Derivatives as Antileukotrienics with a Multiple Activity Mechanism

…, B Brunová, A Jandera, V Kmoníček

Index: Kuchar, Miroslav; Culikova, Katerina; Panajotovova, Vladimira; Brunova, Bohumila; Jandera, Antonin; Kmonicek, Vojtech Collection of Czechoslovak Chemical Communications, 1998 , vol. 63, # 1 p. 103 - 114

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Citation Number: 10

Abstract

Abstract A series of 2, 4-dihydroxy-3-propylacetophenone derivatives containing alkylthiobenzoic or arylacetic acid moiety was prepared. The antileukotrienic activity of the substances was assessed in terms of inhibition of the biosynthesis of LTB 4 and bonding to LTB 4 and LTD 4 receptors. Some of the substances were found to exert a complex antileukotrienic effect in all of the three tests. The compounds also displayed an ...