(4). Their affinities for~-HT~ A receptors range from 0.15 to 28 nM and thus emphasize the importance of N4-substitution. By combining the SAR of these N4-aralkyl series with the recently publishedll SAR of the N4-alkyl-substituted phenylpiperazines, the nature of the interaction of the N4-substituted phenylpiperazines and the B-HT~ A receptor was further examined using comparative molecular field analysis (CoMFA). To discriminate between ...
