Synthesis of novel 1H-1, 2, 3-triazole tethered C-5 substituted uracil–isatin conjugates and their cytotoxic evaluation

K Kumar, S Sagar, L Esau, M Kaur, V Kumar

Index: Kumar, Kewal; Sagar, Sunil; Esau, Luke; Kaur, Mandeep; Kumar, Vipan European Journal of Medicinal Chemistry, 2012 , vol. 58, p. 153 - 159

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Citation Number: 29

Abstract

The present manuscript describes the synthesis of uracil–isatin hybrids via azide–alkyne cycloadditions and their cytotoxic evaluation against three human cancer cell lines viz. HeLa (cervix), MCF-7 (breast) and DU145 (prostate) using MTT assay. The evaluation studies revealed the dependence of cytotoxicity on C-5 substituents of both uracil and isatin as well as the alkyl chain length with compounds 6g and 6k showing IC50 values 18.21 and ...