Synthesis and neurotoxicity profile of 2, 4, 5-trihydroxymethamphetamine and its 6-(N-acetylcystein-S-yl) conjugate

…, U McCann, GA Ricaurte, M Largeron

Index: Neudoerffer, Anne; Mueller, Melanie; Martinez, Claire-Marie; Mechan, Annis; McCann, Una; Ricaurte, George A.; Largeron, Martine Chemical Research in Toxicology, 2011 , vol. 24, # 6 p. 968 - 978

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Citation Number: 4

Abstract

The purpose of the present study was to determine if trihydroxymethamphetamine (THMA), a metabolite of methylenedioxymethamphetamine (MDMA,“ecstasy”), or its thioether conjugate, 6-(N-acetylcystein-S-yl)-2, 4, 5-trihydroxymethamphetamine (6-NAC-THMA), play a role in the lasting effects of MDMA on brain serotonin (5-HT) neurons. To this end, novel high-yield syntheses of THMA and 6-NAC-THMA were developed. Lasting effects of both ...