The adenosine A 2A antagonistic properties of selected C8-substituted xanthines

…, G Terre'Blanche, A Petzer, ACU Lourens, JP Petzer

Index: Van Der Walt, Mietha M.; Terre'Blanche, Gisella; Petzer, Anel; Lourens, Anna C.U.; Petzer, Jacobus P. Bioorganic Chemistry, 2013 , vol. 49, p. 49 - 58

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Citation Number: 12

Abstract

Abstract The adenosine A 2A receptor is considered to be an important target for the development of new therapies for Parkinson's disease. Several antagonists of the A 2A receptor have entered clinical trials for this purpose and many research groups have initiated programs to develop A 2A receptor antagonists. Most A 2A receptor antagonists belong to two different chemical classes, the xanthine derivatives and the amino- ...