Rhodium??Catalyzed Cyclopropenation of Alkynes: Synthesis of Trifluoromethyl??Substituted Cyclopropenes

B Morandi, EM Carreira

Index: Morandi, Bill; Carreira, Erick M. Angewandte Chemie - International Edition, 2010 , vol. 49, # 25 p. 4294 - 4296

Full Text: HTML

Citation Number: 65

Abstract

The trifluoromethyl group is a structural subunit that is extensively relied upon in the drug discovery process in medicinal chemistry. However, its introduction during the course of a synthesis remains a challenge for the organic chemist.[1] Trifluoromethyl-substituted cyclopropenes are potentially highly useful subunits whose synthesis and use have been only sparsely described in the literature.[2] We recently documented an iron-catalyzed ...