Fliposomes: new amphiphiles based on trans-3, 4-bis (acyloxy)-piperidine able to perform a pH-triggered conformational flip and cause an instant cargo release from …

…, AA Yaroslavov, GV Grishina, NM Samoshina…

Index: Samoshin, Andrey V.; Veselov, Ivan S.; Chertkov, Vyacheslav A.; Yaroslavov, Alexander A.; Grishina, Galina V.; Samoshina, Nataliya M.; Samoshin, Vyacheslav V. Tetrahedron Letters, 2013 , vol. 54, # 41 p. 5600 - 5604

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Citation Number: 16

Abstract

Abstract Amphiphilic trans-3, 4-bis (acyloxy)-1-benzylpiperidines able to perform a pH- triggered conformational flip (flipids) have been suggested as components of a new type of pH-sensitive liposomes (fliposomes). According to 1 H NMR, their acid-induced conformational flip occurs in methanol-d 4 when the apparent pD decreases from 6 to 3. The protonation-generated intramolecular hydrogen bond and electrostatic interactions make ...