e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Tetrahedron letters
An efficient synthesis of 4-bromo-N-substituted oxindoles by an intramolecular copper-catalyzed amidation reaction
A van den Hoogenband, JHM Lange, JAJ den Hartog…
Index: van den Hoogenband, Adri; Lange, Jos H.M.; den Hartog, Jack A.J.; Henzen, Remco; Terpstra, Jan Willem Tetrahedron Letters, 2007 , vol. 48, # 26 p. 4461 - 4465
A highly efficient synthetic approach to novel 4-bromo-N-substituted oxindoles is described. The method involves a mild intramolecular copper-catalyzed amidation reaction of N- substituted 2, 6-dibromophenylacetamides. In contrast to our recently published palladium- catalyzed amidation reaction, no concomitant dimerization on the 3-position of the formed oxindole occurs.
