Side-chain-anchored N α-Fmoc-Tyr-OPfp for bidirectional solid-phase synthesis

…, SH Hansen, M Witt, JW Jaroszewski, H Franzyk

Index: Jorgensen, Malene R.; Olsen, Christian A.; Mellor, Ian R.; Usherwood, Peter N. R.; Witt, Matthias; Franzyk, Henrik; Jaroszewski, Jerzy W. Journal of Medicinal Chemistry, 2005 , vol. 48, # 1 p. 56 - 70

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Citation Number: 9

Abstract

A mild resin-immobilization strategy employing a readily prepared trityl bromide resin for anchoring building blocks via a phenol group has been developed. With N α-Fmoc-Tyr-OPfp as a starter building block, it was possible to prepare asymmetrically substituted hybrids of spider-and wasp-type polyamine toxins using solid-phase peptide synthesis conditions.