Abstract Two new series of new compounds containing a 6-amino-substituted group or 6- acrylamide-substituted group linked to a 4-anilinoquinazoline nucleus have been discovered as potential EGFR inhibitors. These compounds proved efficient effects on antiproliferative activity and EGFR–TK inhibitory activity. Especially, N 6-((5-bromothiophen- 2-yl) methyl)-N 4-(3-chlorophenyl) quinazoline-4, 6-diamine (5e), showed the most potent ...
