Lithium ammonia reductions of 2-thiophenecarboxylic acids

WG Blenderman, MM Joullie…

Index: Blenderman, Walter G.; Joullie, Madeleine M.; Preti, George Journal of Organic Chemistry, 1983 , vol. 48, # 19 p. 3206 - 3213

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Citation Number: 18

Abstract

H3C fiC0, H lb thiophenecarboxylic acid (la) was available in larger quantities than lb, conversion of la to (2)-3-penten-1-01 was examined first. Desulfurization of (2)-5-mercapto-3- pentenoic acid (4a) with W-2 hey nickello did not afford the desired (2)-3-pentenoic acid (sa) but a mixture of isomers. Reduction of this carboxylic acid mixture using lithium aluminum hydride afforded the corresponding mixture of isomeric alcohols. Analysis of GC/MS and ...