Synthesis and biological evaluation of (2, 5-dihydro-1H-pyrrol-1-yl)-2H-chromen-2-ones as free radical scavengers

A Balabani, DJ Hadjipavlou-Litina, KE Litinas…

Index: Balabani, Anna; Hadjipavlou-Litina, Dimitra J.; Litinas, Konstantinos E.; Mainou, Maria; Tsironi, Crystal-Catherine; Vronteli, Anastasia European Journal of Medicinal Chemistry, 2011 , vol. 46, # 12 p. 5894 - 5901

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Citation Number: 25

Abstract

The allylation of aminocoumarins in the presence of excess of anhydrous K2CO3 and allyl bromide to diallylaminocoumarins is described. The Ring Closing Metathesis reaction of the later with the Grubbs' 1rst generation catalyst under reflux or MW irradiation has resulted mainly to (2, 5-dihydro-1H-pyrrol-1-yl) coumarins and (1H-pyrrol-1-yl) coumarins. The new compounds were tested in vitro for their ability:(i) to interact with 1, 1-diphenyl-2-picryl- ...