Macamides and their synthetic analogs: evaluation of in vitro FAAH inhibition

…, CJ Kelley, A Pino-Figueroa, HD Vu, TJ Maher

Index: Wu, Hui; Kelley, Charles J.; Pino-Figueroa, Alejandro; Vu, Huyen D.; Maher, Timothy J. Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 17 p. 5188 - 5197

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Citation Number: 21

Abstract

Abstract Maca (Lepidium meyenii), a traditional food crop of the Peruvian Andes is now widely touted as a dietary supplement. Among the various chemical constituents isolated from the plant are a unique series of non-polar, long-chain fatty acid N-benzylamides known as macamides. We have synthesized 11 of the 19 reported macamides and have tested each as potential inhibitors of the human enzyme, fatty acid amide hydrolase (FAAH). The ...