Journal of heterocyclic chemistry

An efficient synthesis of 3, 5??dimethoxyhomophthalic acid, a key intermediate for synthesis of natural isocoumarins

A Saeed, NH Rama, M Arfan

Index: Saeed, Aamer; Rama, Nasim H.; Arfan Journal of Heterocyclic Chemistry, 2003 , vol. 40, # 3 p. 519 - 522

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Citation Number: 11

Abstract

Abstract 3, 5-Dimethoxyhomophthalic acid was prepared efficiently in three steps, from 3, 5- dimethoxybenzyl bromide via rhodium-catalyzed direct carbonylation to 3, 5- dimethoxyphenylacetic acid followed by successive o-formylation and oxidation. Isocoumarins related to agrimonolide and achlisocoumarin 1 were prepared in single step by condensation of the homophthalic acid with appropriate acid chlorides.