e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Synthesis
A new approach to the synthesis of polyfunctionally substituted 1, 8-naphthyridin-2-one derivatives from 6-azidopyridones: A novel thermal decomposition to 6- …
Abstract: Azidation of the chloroaldehyde 2, which was obtained from the 6-hydroxy-2- pyridones 1, afforded the 6-azido-2-pyridones 3. Compound 3 can be converted to the corresponding 6-amino-2-pyridones 5, by the reaction with triphenylphosphine via phosphazenes and subsequent hydrolysis (Staudinger reaction). This obtained amine 5 reacts with ethyl cyanoacetate in an ethanolic solution containing piperidine to give 7- ...
