Hydrogenolysis of the C O bond of the 1, 2, 4??oxadiazine ring. Adams platinum hydrogenation of 3??aryl??5, 6??dihydro??5??(substituted)??methylene??4H??1, 2, 4?? …

E Kawashima, T Takada, K Tabei…

Index: Kawashima, Etsuko; Takada, Toyozo; Tabei, Katsumi Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 1409 - 1412

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Citation Number: 6

Abstract

Abstract Adams platinum hydrogenation of Z-3-aryl-5, 6-dihydro-5-(substituted) methylene- 4H-1, 2, 4-oxadiazine (1a-f) proceeds very slowly through C [BOND] O bond fission to give N- (1-substitutedcarbonyl-2-propylidene) benzamide ox-ime derivative 2 as the main product. In the reaction of 5-(arylcarbamoyl) methylene analogues 1d-f, 5-(aryl-carbamoyl) methyl-5, 6-dihydro-3-phenyl-4H-1, 2, 4-oxadiazine (4) and N-aryl-3-hydroxybutanamide derivative ...