β2??and β3??Peptides with Proteinaceous Side Chains: Synthesis and solution structures of constitutional isomers, a novel helical secondary structure and the influence …

…, K Gademann, G Guichard, T Hintermann…

Index: Seebach, Dieter; Abele, Stefan; Gademann, Karl; Guichard, Gilles; Hintermann, Tobias; Jaun, Bernhard; Matthews, Jennifer L.; Schreiber, Juerg V.; Oberer, Lukas; Hommel, Ulrich; Widmer, Hans Helvetica Chimica Acta, 1998 , vol. 81, # 5 p. 932 - 982

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Citation Number: 360

Abstract

Abstract Enantiomerically pure β-amino-acid derivatives with the side chains of Ala, Val, and Leu in the 2-or 3-position (β 2-and β 3-amino acids, resp.), as well as with substituents in both the 2-and 3-positions (β 2, 3-amino acids, of like-configuration) have been prepared (compounds 8–17) and incorporated (by stepwise synthesis and fragment coupling, intermediates 24–34) into β-hexa-, β-hepta-, and β-dodecapeptides (1–17). The new and ...