Discovery of N-[[1-[2-(tert-butylcarbamoylamino) ethyl]-4-(hydroxymethyl)-4-piperidyl] methyl]-3, 5-dichloro-benzamide as a selective T-type calcium channel (Ca v 3.2) …

…, QD Wang, A Lindqvist, Å Högberg, E Lindhardt…

Index: Giordanetto, Fabrizio; Wallberg, Andreas; Knerr, Laurent; Selmi, Nidhal; Ullah, Victoria; Thorstensson, Fredrik; Lindelo, Asa; Karlsson, Staffan; Nikitidis, Grigorios; Llinas, Antonio; Wang, Qing-Dong; Lindqvist, Anders; Hoegberg, Agot; Lindhardt, Emma; Astrand, Annika; Duker, Goeran Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 1 p. 119 - 124

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Citation Number: 3

Abstract

The T-type calcium channel inhibitor Mibefradil was reported to protect the heart from atrial remodeling, a key process involved in the development of atrial fibrillation and arrhythmias. Mibefradil is not a selective T-type calcium channel inhibitor and also affects the function of different ion channels. Our aim was to develop a selective T-type calcium channel inhibitor to validate the importance of T-type-related pharmacology in atrial fibrillation. Structural ...