A potent, long-acting, orally active (2 R)-2-[(1 R)-3, 3-Difluorocyclopentyl]-2-hydroxy-2-phenylacetamide: a novel muscarinic M3 receptor antagonist with high …

M Mitsuya, K Kobayashi, K Kawakami…

Index: Journal of Medicinal Chemistry, , vol. 43, # 26 p. 5017 - 5029

Full Text: HTML

Citation Number: 44

Abstract

... Journal of Medicinal Chemistry. ... Thus, pharmaceutical research into therapeutic agents selective for muscarinic receptor subtypes has recently focused on the development of an M 3 selective antagonist for the treatment of urinary tract disorders such as urinary incontinence ...

Synthesis and Structure–Activity Relationships of Indazole A...

[Procopiou, Panayiotis A.; Barrett, John W.; Barton, Nicholas P.; Begg, Malcolm; Clapham, David; Copley, Royston C. B.; Ford, Alison J.; Graves, Rebecca H.; Hall, David A.; Hancock, Ashley P.; Hill, Alan P.; Hobbs, Heather; Hodgson, Simon T.; Jumeaux, Coline; Lacroix, Yannick M. L.; Miah, Afjal H.; Morriss, Karen M. L.; Needham, Deborah; Sheriff, Emma B.; Slack, Robert J.; Smith, Claire E.; Sollis, Steven L.; Staton, Hugo Journal of Medicinal Chemistry, 2013 , vol. 56, # 5 p. 1946 - 1960]