Synthesis and characterization of metabolites and potential impurities of lansoprazole, an antiulcerative drug

GM Reddy, K Mukkanti, TL Kumar…

Index: Reddy, Ganta Madhusudhan; Mukkanti; Kumar, T. Laxmi; Babu, J. Moses; Reddy, Padi Pratap Synthetic Communications, 2008 , vol. 38, # 20 p. 3477 - 3489

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Citation Number: 12

Abstract

Abstract Lansoprazole (Prevacid) is an antiulcerative drug used for the treatment of duodenal and gastric ulcers, reflux oesophagitis, and Zollinger–Ellison syndrome. During the bulk synthesis of lansoprazole, we have observed five impurities: lansoprazole N-oxide, lansoprazole sulfone N-oxide, lansoprazole sulfide, lansoprazole sulfone and N-aralkyl lansoprazole. The present work describes the synthesis and characterization of these ...