Correlation between antigen-combining-site structures and functions within a panel of catalytic antibodies generated against a single transition state analog

I Fujii, F Tanaka, H Miyashita, R Tanimura…

Index: Fujii, Ikuo; Tanaka, Fujie; Miyashita, Hideaki; Tanimura, Ryuji; Kinoshita, Keiko Journal of the American Chemical Society, 1995 , vol. 117, # 23 p. 6199 - 6209

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Citation Number: 72

Abstract

Abstract: The diversity of the immune response, which can provide a panel of catalytic antibodies with varying degrees of catalytic activity and substrate specificity by immunization with a single hapten, raises the question concerning the extent to which a rationally designed hapten dictates the paratopes for catalytic function in the antigencombining site. We have investigated the biochemical properties within a panel of six hydrolytic catalytic ...