Synthesis and transformations of γ-chlorobutanoic acid phenyl (ethyl) amide

NN Yusubov, VM Ismailov, ZA Mamedova

Index: Yusubov; Ismailov; Mamedova Russian Journal of Organic Chemistry, 2007 , vol. 43, # 10 p. 1571 - 1572

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Abstract

Trimethylenecarbonyl fragment is a structural base of many biologically active compounds [1, 2]. A convenient synthon for introducing this fragment is γ-chlorobutyryl chloride. It was previously established [3, 4] that alkoxybenzenes acylation with γ-chlorobutyryl chloride led to the formation of heterocyclic compounds. In this study we investigated the acylation of N- ethylaniline with γ-chlorobutyryl chloride that proceeded with the formation of the ...