Synthesis, biodistribution and micro-PET imaging of radiolabeled antimitotic agent T138067 analogues

…, QH Zheng, JQ Wang, KL Stone, TD Martinez…

Index: Fei, Xiangshu; Zheng, Qi-Huang; Wang, Ji-Quan; Stone, K. Lee; Martinez, Tanya D.; Miller, Kathy D.; Sledge, George W.; Hutchins, Gary D. Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 5 p. 1247 - 1251

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Citation Number: 9

Abstract

Radiolabeled antimitotic agents [11C] T138067 and [18F] T138067 have been synthesized for evaluation as new potential positron emission tomography (PET) biomarkers for cancer imaging. In vivo biodistribution and micro-PET imaging of [11C] T138067 were performed in breast cancer animal models MCF-7 transfected with IL-1α implanted athymic mice and MDA-MB-435 implanted athymic mice. The results suggest that the uptakes of [11C] ...