Increment of antimycobaterial activity on lichexanthone derivatives

A Camila Micheletti, N Kika Honda…

Index: Micheletti, Ana Camila; Honda, Neli Kika; Pavan, Fernando R.; Leite, Clarice Q.F.; De Fatima Cepa Matos, Maria; Perdomo, Renata Trentin; Bogo, Danielle; Alcantara, Glaucia Braz; Beatriz, Adilson Medicinal Chemistry, 2013 , vol. 9, # 7 p. 904 - 910

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Citation Number: 4

Abstract

A new dihydropyranexanthone derived from the natural xanthone lichexanthone (1) was synthesised and, together with other 18 derivatives including ω-bromo and ω- aminoalkoxylxanthones (containing methyl, ethyl, propyl, tertbutylamino and piperidinyl moieties), were tested against Mycobacterium tuberculosis. Nine ω-aminoalkoxylxanthones showed good antimycobacterial activity, and their in vitro cytotoxicity was determined ...