A straightforward route to isomurralonginol (1) from umbelliferone (4 steps, 59% yield) is described. Isomurralonginol is used as the key intermediate in the preparation of isomurralonginol acetate (2)(1 step, 94% yield), murralongin (3)(1 step, 75% yield) and microminutin (2 steps and 38% yield). The synthesis of microminutin involves the selenolactonization of α, β-substituted vinyl acetic acid (12)(50% yield) with spontaneous ...
