Abstract The palladium-catalyzed coupling reaction of arylboronicacids with ethyl glyoxylate provides a straightforward method for the synthesis of mandelic esters. Pd 2 (dba) 3· CHCl 3 in combination with 2-di-tert-butylphosphanylbiphenyl as the catalytic system and Cs 2 CO 3 as the base were used. The reaction tolerates a wide range of functionalized boronicacids. Mandelic esters were isolated in good-to-excellent yields with a variety of neutral, slightly ...
