Rhodanines and related five-membered heterocycles with multiple heteroatoms have recently gained a reputation of being unselective compounds that appear as “frequent hitters” in screening campaigns and therefore have little value in drug discovery. However, this judgment appears to be based mostly on anecdotal evidence. Having identified various rhodanines and related compounds in screening campaigns, we decided to perform a ...
![(5E)-5-[(3-hydroxyphenyl)methylidene]-2-sulfanylideneimidazolidin-4-one Structure](https://image.chemsrc.com/caspic/292/74920-46-0.png)
![5-[(3,4-dihydroxyphenyl)methyl]imidazolidine-2,4-dione Structure](https://image.chemsrc.com/caspic/412/62715-12-2.png)
![5-[(4-aminophenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one Structure](https://image.chemsrc.com/caspic/147/99361-26-9.png)