The Journal of organic chemistry

New synthetic route to 2-pyridones and its application toward the synthesis of (±)-ipalbidine

SM Sheehan, A Padwa

Index: Sheehan, Scott M.; Padwa, Albert Journal of Organic Chemistry, 1997 , vol. 62, # 3 p. 438 - 439

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Citation Number: 64

Abstract

Six-membered nitrogen heterocycles comprise the backbone of many biologically and structurally interesting alkaloids. 1, 2 The 3-hydroxy-2 (1H)-pyridone (4) ring system is a valuable building block in natural product synthesis, 3 as it can act as a common intermediate for the preparation of a wide variety of piperidine, pyridine, quinolizidine, and indolizidine alkaloids. 2, 4 Only a few methods of preparing 3-hydroxy-2 (1H)-pyridones ...