Synthesis and antifungal activity of 6-arylthio-/6-arylamino-4, 7-dioxobenzothiazoles

…, KU Choi, JY Shim, HJ You, IH Choi, MJ Chae

Index: Ryu, Chung-Kyu; Choi, Ko Un; Shim, Ju-Yeon; You, Hea-Jung; Choi, Ik Hwa; Chae, Mi Jin Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 18 p. 4003 - 4008

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Citation Number: 58

Abstract

6-Arylthio-/6-arylamino-4, 7-dioxobenzothiazoles were synthesized and tested for in vitro antifungal activity against Candida species and Aspergillus niger. 6-Arylamino-4, 7- dioxobenzothiazoles 5 and 6 showed, in general, more potent antifungal activity than 6- arylthio-4, 7-dioxobenzothiazoles 3 and 4. The 6-arylamino-substituted compounds 5 and 6 exhibited the greatest activity. In contrast, 6-arylthio-, 2-/5-methyl-or 5-methoxy-moieties of ...