e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Tetrahedron
1, 4-Addition of arylboronic acids to β-aryl-α, β-unsaturated ketones and esters catalyzed by a rhodium (I)–chiraphos complex for catalytic and enantioselective …
…, H Tachikawa, Y Kobayashi, Y Yamamoto, N Miyaura
An enantioselective synthesis of acyclic β-diaryl ketones and esters via 1, 4-addition of arylboronic acids to β-aryl-α, β-unsaturated ketones or esters is described. The complex in situ prepared from [Rh (nbd) 2] BF4 and chiraphos was found to be an excellent catalyst to achieve high enantioselectivities in a range of 83–89% ee for the ketone derivatives and 78– 94% ee for tert-butyl β-arylacrylate derivatives. The protocol provided a catalytic method ...
