Design, Synthesis, and Structure–Activity Relationship of Novel LSD1 Inhibitors Based on Pyrimidine–Thiourea Hybrids As Potent, Orally Active Antitumor Agents

…, M Zhang, JW Wang, L Ding, J Li…

Index: Choi, Yongseok; Li, Ling; Grill, Sue; Gullen, Elizabeth; Lee, Chang Soo; Gumina, Giuseppe; Tsujii, Eisaku; Cheng, Yung-Chi; Chu, Chung K. Journal of Medicinal Chemistry, 2000 , vol. 43, # 13 p. 2538 - 2546

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Citation Number: 20

Abstract

Histone lysine specific demethylase 1 (LSD1) was reported to be overexpressed in several human cancers and recognized as a promising anticancer drug target. In the current study, we designed and synthesized a novel series of pyrimidine–thiourea hybrids and evaluated

SYNTHESIS AND IN VITRO ANTI-HCV ACTIVITY OF β-D-and L-2′-DEO...

[Shi, Junxing; Du, Jinfa; Ma, Tianwei; Pankiewicz, Krzysztof W.; Patterson, Steven E.; Hassan, Abdalla E. A.; Tharnish, Phillip M.; McBrayer, Tamara R.; Lostia, Stefania; Stuyver, Lieven J.; Watanabe, Kyoichi A.; Chu, Chung K.; Schinazi, Raymond F.; Otto, Michael J. Nucleosides, Nucleotides and Nucleic Acids, 2005 , vol. 24, # 5-7 p. 875 - 879]