Abstract: Optically active ene carbamates were a-lithiated by lithium tetramethylpiperidide in the presence of trialkylstannyl chlorides to produce a-stannylated compounds. These underwent facile palladium-catalyzed couplings with acid chlorides to produce a-keto ene carbamates in good yield. Treatment of the a-stannyl ene carbamates with butyllithium followed by quenching with carbon dioxide and esterification gave optically active ...
