Methoxy-substituted benzamides containing 2-pyrrolidinylmethyl side chains are selective and biologically potent dopamine D2 receptor antagonists, which when used clinically display minimal deleterious side Included in this class of neuroleptics is the 2, 3-dimethoxy-5- iodobenzamide la (Chart I), also known as epidepride, which has recently been shown to possess high affinity in