Quinoline Carboxamide??Type ABCG2 Modulators: Indole and Quinoline Moieties as Anilide Replacements

S Bauer, C Ochoa??Puentes, Q Sun, M Bause…

Index: Bauer, Stefanie; Ochoa-Puentes, Cristian; Sun, Qiu; Bause, Manuel; Bernhardt, Guenther; Koenig, Burkhard; Buschauer, Armin ChemMedChem, 2013 , vol. 8, # 11 p. 1773 - 1778

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Citation Number: 6

Abstract

The ATP-driven drug efflux transporters ABCB1 (p-glycoprotein, p-gp), ABCC1 (MRP1), and ABCG2 (breast cancer resistance protein, BCRP) play an important role in multidrug resistance (MDR) of cancer.[1] In addition, the chemotherapy of malignant central nervous system (CNS) tumors is compromised due to the expression of ABC proteins at the blood– brain barrier, restricting the access of many potent cytostatics to the brain, in the case that ...