Synthesis and Conformational Analysis of the T??Antigen Disaccharide (β??D??Gal??(1→ 3)?螃窿?D??GalNAc??OMe)

R Bukowski, LM Morris, RJ Woods…

Index: Bukowski, Ralph; Morris, Laura M.; Woods, Robert J.; Weimar, Thomas European Journal of Organic Chemistry, 2001 , # 14 p. 2697 - 2705

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Citation Number: 21

Abstract

Abstract We report an improved synthesis of the T-antigen disaccharide [β-D-Gal-(1 [RIGHTWARDS ARROW] 3)-α-D-GalNAc-OMe], incorporating recycling of the undesired β- glycosyl acceptor [methyl 2-azido-4, 6-benzylidene-2-deoxy-β-D-galactopyranoside (9β)] through anomerization by treatment with FeCl 3. The conformational analysis of the disaccharide made use of high quality NOE data in combination with extensive Metropolis ...